13-P036 Body length is defined by the endogenous balance of retinoid and fibroblast growth factor signalling
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چکیده
منابع مشابه
13-P036 Body length is defined by the endogenous balance of retinoid and fibroblast growth factor signalling
Arteriovenous malformations (AVMs) are the major cause of haemorrhagic stroke in young adults, but the causal factors leading to AVM formation are unknown. An important clue is provided by the familial human disease Hereditary Haemorrhagic Telangiectasia (HHT), which is characterised by multi-organ AVMs and bleeding. HHT is inherited in an autosomal dominant manner and most patients carry mutat...
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diapause. Pafr protein was present in a membrane bound form in the glandular epithelium of the endometrium across all stages, analysis studies are in progress to determine any temporal changes in levels of expression. In vitro, paf production from the endometrium increases after diapause (Kojima et al., 1993). p53 expression assessed by RT-PCR, was detected in the endometrium across all stages ...
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Senataxin is encoded by the SETX gene and is mainly involved in two different neurodegenerative diseases, the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia with oculomotor apraxia type 2. Based on protein homology, senataxin is predicted to be a putative DNA/RNA helicase, while senataxin interactors from patients' lymphoblast cell lines suggest a ...
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Ligand-dependent signalling pathways have been characterised as having morphogen properties where there is a quantitative relationship between receptor activation and response, or threshold characteristics in which there is a binary switch in response at a fixed level of receptor activation. Here we report the use of a bacterial artificial chromosome (BAC)-based transgenic system in which a hyp...
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Signalling by fibroblast growth factors (FGFs) through FGF receptors (FGFRs) depends on the cell-surface polysaccharide heparan sulphate (HS) [1] [2]. HS has an ordered domain structure of highly diverse saccharide motifs that present unique displays of sulphate, carboxyl and hydroxyl groups [3]. These motifs interact with many proteins, particularly growth factors. HS binds both to FGFs [4] [5...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.509